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Vinflunine tartrate Size:Solid 10 mg 1007/s12325-014-0141-9

SKU: 95834621591

4.2
SEK119.00 SEK154.00

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Vinflunine tartrate Size:Solid 10 mg 1007/s12325-014-0141-9Vinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.

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Description

1007/s12325-014-0141-9

CID53347902

At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50 of 10 to 30 nmol/L)

CAS Number: 1197300-24-5

Vinflunine tartrate Size:Solid 10 mg 1007/s12325-014-0141-9Vinflunine is a bi fluorinated derivative of the semi synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis.

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