ARRY-520 (R) 30002 Smiles: CC(C)OC1C=CC(=CC=1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC=CC=C21

Smiles: CC(C)OC1C=CC(=CC=1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC=CC=C21

Devereux S

Absorption is relatively rapid in dogs but slower in mice (10 mg/kg)

TH588 was dosed to the mice by subcutaneous administration at 30 mg/kg once per day for 21 days

ARRY-520 (R) 30002 Smiles: CC(C)OC1C=CC(=CC=1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC=CC=C21ARRY 520 R enantiomer is the R form of ARRY 520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY 520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Product