HG-10-102-01 - LRRK2 Inhibitor. CAS# 1351758-81-0 size:2mg solid 4-DPCA is found to be

4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04

21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H

(2017) Cancer Lett

HG-10-102-01 - LRRK2 Inhibitor. CAS# 1351758-81-0 size:2mg solid 4-DPCA is found to beHG 10 102 01, CAS No. 1351758 81 0, is a brain penetrant, potent and selective inhibitor of wild type LRRK2 and the G2019S mutant (IC50 for LRRK2 wild type ~20. 3 nM and LRRK2 [G2019S] ~3. 2 nM). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild type LRRK2 and G2019S mutant at a concentration of 0. 10. 3 M in cells. HG 10 102 01 is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse