CCT129202 - CAS# 942947-93-5 10575 Honokiol is highly effective against

Honokiol is highly effective against SVR angiosarcoma in nude mice

InChi: InChI=1S/C31H44N2O5S

a serine/threonine protein kinase overexpressed in certain types of cancer cells

A 100-fold higher concentration (2–8 μM) of E6446 was required to inhibit TLR7/8 activated by the imidazoquinoline compound R848

CCT129202 - CAS# 942947-93-5 10575 Honokiol is highly effective againstCCT129202 is an inhibitor of Aurora kinase activity and displays a favorable antineoplastic effect in preclinical studies. CCT129202 significantly reversed ABCB1 and ABCG2 mediated MDR in vitro, in vivo and ex vivo by inhibiting the function of their transporters and enhanced the eradication of cancer stem like cells by chemotherapeutic agents. CCT129202 may be a candidate as MDR reversal agent for antineoplastic combination therapy and merits further