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ONT-093 - CAS# 216227-54-2 0154 24-12)16(18)22/h8

ONT-093 - CAS# 216227-54-2 0154 24-12)16(18)22/h8

Name: ONT-093 - CAS# 216227-54-2 0154 24-12)16(18)22/h8
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ONT-093 - CAS# 216227-54-2 0154 24-12)16(18)22/h8ONT 093, CAS No. 216227 54 2, also known as OC 144 093, is an orally bioavailable P glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT 093 could inhibit P gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. OC144 093 is the least non specifically toxic Pgp inhibitor described to date, with an average cytostatic IC50 of >60

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Description

24-12)16(18)22/h8

) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice

Pérez-Medina C

(2011) Cancer Research

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