LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 I-BRD9 was used at 10

I-BRD9 was used at 10 µM final concentration in vitro and in cellular assays

It showed selectivity for Ral relative to the GTPases Ras and RhoA and inhibited tumour xenograft growth to a similar extent to the depletion of Ral using RNA interference

Angew Chem Int Ed Engl

515(7527):443-7

LY294002 - PI3K/BET Dual Inhibitor. CAS# 154447-36-6 6057 I-BRD9 was used at 10LY294002, CAS No. 154447 36 6, is a potent and selective small molecule PI3K inhibitor, inhibits PI3K with IC50 of 0. 5 M, 0. 57 M and 0. 97 M, respectively. It is the most widely used PI3K inhibitor to study the role of phosphoinositide 3 kinases in the signal transduction pathways involved in cell migration, proliferation, survival, and metabolism. LY294002 inactivates Akt PKB, consequently inhibiting cell proliferation and inducing apoptosis. It is