PND-1186 Catalog No.:M9572-10 PHA-665752 inhibited lung tumorigenesis in

PHA-665752 inhibited lung tumorigenesis in Kras(LA1) mice and may provide a novel therapeutic approach to the prevention of K-ras-mutant NSCLC

Formula: C17H17ClN2O5

Fiedler MA

GW-9662 has nanomolar IC50 versus PPARγ and is 10- and 600-fold less potent in binding experiments using PPARα and PPARδ

PND-1186 Catalog No.:M9572-10 PHA-665752 inhibited lung tumorigenesis inPND 1186, also known as SR 2156 and VS 4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1. 5 nM in vitro. PND 1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1. 0 M PND 1186 (>5 fold above IC50) had limited effects on cell proliferation. However, under non adherent conditions as spheroids and as colonies in soft agar, 0. 1 M PND 1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase 3