Defactinib HCl - CAS# 1073160-26-5 Catalog No.:M7055-2 most selective 5- HT2B receptor

most selective 5- HT2B receptor ligands

E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

30 min prior to UVB irradiation for 30 weeks) suppresses development of squamous cell carcinoma in SKH-1 hairless mice

5-dihydroimidazol-1-yl]-phenylmethanone

Defactinib HCl - CAS# 1073160-26-5 Catalog No.:M7055-2 most selective 5- HT2B receptorDefactinib HCl, CAS No. 1073160 26 5, also known as VS 6063 and PF 04554878, is an orally bioavailable, small molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF 04554878 inhibits FAK, which may prevent the integrin mediated activation of several downstream signal transduction pathways, including ERK, JNK MAPK and PI3K Akt, thus inhibiting tumor cell migration, proliferation and