Fenretinide - CAS# 65646-68-6 127 Zajac-Kaye M

Zajac-Kaye M

(2008) J Med Chem

A decrease in CMA activity occurs in aging and in age-related disorders (such as neurodegenerative diseases and diabetes)

4SC-202 was used at 10µM final concentration in various in vitro assays

Fenretinide - CAS# 65646-68-6 127 Zajac-Kaye MFenretinide, CAS No. 65646 68 6, is an orally active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis associated growth factors and their receptors and exhibits retinoid