ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 size:2mg solid The MDL29951-activated receptor exhibits other

The MDL29951-activated receptor exhibits other activities associated with GPCR-mediated signaling

MK-1775 was orally dosed to mice at 20 mg/Kg once per day

HLY78 was used at 10-20 µM final concentration in various in vitro assays

InChiKey: XZZHOJONZJQARN-UHFFFAOYSA-N

ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 size:2mg solid The MDL29951-activated receptor exhibits otherITD 1, CAS No. 1099644 42 4, is a novel and highly selective TGF pathway inhibitor identified by a high throughput, embryonic stem cell (ESC) cardiac differentiation screening. ITD 1 promoted cardiomyocyte differentiation specifically via degradation of the TGF type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 0. 40. 8 M), revealing a role for TGF signaling