Diphylline ntin) Smiles: FC(F)C1=NC2=CC=CC=C2N1C1N=C(N=C(N=1)N1CCOCC1)N1CCOCC1

Smiles: FC(F)C1=NC2=CC=CC=C2N1C1N=C(N=C(N=1)N1CCOCC1)N1CCOCC1

PubMed Central PMCID: PMC4264672

5-trien-7-yl]methyl}((²H₃)methyl)amino)propyl]-7

The pyridine regio-isomer GSK-J2 displays significantly less on-target activity (IC50 > 100 µM for human JmjD3) and thus can be used as control for target effects in vitro

Diphylline ntin) Smiles: FC(F)C1=NC2=CC=CC=C2N1C1N=C(N=C(N=1)N1CCOCC1)N1CCOCC1Dyphylline is a phosphodiesterase inhibitor used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. It also acts as an adenosine receptor antagonist. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other