IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 Litchfield DW

Litchfield DW

InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9

AZD-2281 increases vascular perfusion in Calu-6 tumors established in a DWC model

and p62 degradation

IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 Litchfield DWIRE 3, CAS No. 1414938 21 8, is a highly potent and selective small molecule modulator of IRE1. Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase endoRNase (RNase) IRE1. IRE1 oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Interestingly, IRE 3 inhibits the XBP1 mRNA splicing through binding to