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BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 PARP-2 and other ARDT enzymes

BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 PARP-2 and other ARDT enzymes

Name: BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 PARP-2 and other ARDT enzymes
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SKU: 64437609964
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SKU: 64437609964

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BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 0165 PARP-2 and other ARDT enzymesBAY 87 2243, CAS No. 1227158 85 1, is a highly potent and selective inhibitor of hypoxia induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87 2243 mproves local tumor control after fractionated irradiation in a schedule dependent manner in head and neck human xenografts. BAY 87 2243 markedly decreased nuclear HIF 1 expression and pimonidazole hypoxic fraction already after 3 days of drug treatment.

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Description

PARP-2 and other ARDT enzymes

Bornmann W

Laughlin JD

2ClH/c26-23(27)20-8-6-18(7-9-20)16-25-12-10-17(11-13-25)15-24-22-14-21(22)19-4-2-1-3-5-19

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