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HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat induces growth inhibition and apoptosis

HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat induces growth inhibition and apoptosis

Name: HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat induces growth inhibition and apoptosis
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SKU: 56440748498
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SKU: 56440748498

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SEK145.00 SEK172.00

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HI-TOPK-032 - TOPK inhibitor. CAS# 487020-03-1 stat induces growth inhibition and apoptosisHI TOPK 032 is a potent and selective TOPK inhibitor. HI TOPK 032 also reduces ERK RSK phosphorylation, regulates of the abundance of p53, cleaved caspase 7, and cleaved PARP, and induces apoptosis in cancer cells. In vitro, HI TOPK 032 strongly suppressed TOPK kinase activity but had little effect on extracellular signalregulated kinase 1 (ERK1), c junNH2kinase 1, or p38 kinase activities. HI TOPK 032 also inhibited anchorage dependent and

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Description

induces growth inhibition and apoptosis in human gastric cancer cells

(2003) Nature

Int J Mol Med

GW-9662 has nanomolar IC50 versus PPARγ and is 10- and 600-fold less potent in binding experiments using PPARα and PPARδ

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