RG7112 - CAS# 939981-39-2 Catalog No.:M10990-10 Akt inhibitor GSK2141795 binds to

Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt

Acta Orthopaedica Scandinavica Supplementum

Obatoclax binds to members of the Bcl-2 protein family

cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists

RG7112 - CAS# 939981-39-2 Catalog No.:M10990-10 Akt inhibitor GSK2141795 binds toRO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53