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BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Molecular Weight: 731

BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Molecular Weight: 731

Name: BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Molecular Weight: 731
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BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S Molecular Weight: 731BIBW2992 (Afatinib), CAS No. 439081 18 2, is a highly potent and selective irreversible EGFR inhibitor, inhibiting EGFRwt, EGFRL858R, EGFRL858R T790M and HER2 with IC50 of 0. 5 nM, 0. 4 nM, 10 nM, 14 nM, respectively. BIBW2992 suppresses transformation in isogenic cell based assays, inhibits survival of cancer cell lines, exhibits potent effects on both EGFR and HER2 phosphorylation, and induces tumor regression in xenograft and transgenic lung cancer

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Molecular Weight: 731

4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide

Formula: C19H17NO3

but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone

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