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MAK-683 - CAS# 1951408-58-4 size:10mg solid 3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H

MAK-683 - CAS# 1951408-58-4 size:10mg solid 3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H

Name: MAK-683 - CAS# 1951408-58-4 size:10mg solid 3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H
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MAK-683 - CAS# 1951408-58-4 size:10mg solid 3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11HMAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED

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Description

3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16/h4-11H

J Dermatolog Treat

The corresponding cAC10-L4-MMAF4 ADC was much less toxic

Prinaberel (2mg/mouse

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