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INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate ClH/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31

INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate ClH/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31

Name: INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate ClH/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31
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INCB 3284 dimesylate - CAS# 887401-93-6 toprolol tartrate ClH/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31INCB3284 is a potent, selective, and orally bioavailable hCCR2 Antagonist. INCB3284 exhibited an IC50 of 3. 7 nM in antagonism of monocyte chemoattractant protein 1 binding to hCCR2, an IC50 of 4. 7 nM in antagonism of chemotaxis activity, an IC50 of 84 M in inhibition of the hERG potassium current, a free fraction of 58% in protein binding, high selectivity over other chemokine receptors and G protein coupled receptors, and acceptable oral

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ClH/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31

Abstract DDT02-01: GDC-0068: A novel

with inhibition of proliferation and invasion of MDA-MB-231 non-IBC cells at higher concentrations

CAS Number: 290297-26-6

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