Bestatin DEVD-FMK 10 mM abolishes ABCG2 activity

10 mM abolishes ABCG2 activity

sensitizes melanoma cells to therapy

3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid

and enhanced the anti-tumor efficacy of these agents selectively in p53-deficient tumor cells

Bestatin DEVD-FMK 10 mM abolishes ABCG2 activityUbenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer