WZ3146 Size:10mg solid a dramatic increase in caspase-3

a dramatic increase in caspase-3 activity (6-10-fold relative to control or TRAIL alone) is observed

InChi: InChI=1S/C18H15FN4O3S/c1-12-9-14(13-7-8-20-21-11-13)10-16(17(12)19)18(24)22-23-27(25

PF-06447475 is well tolerated in rats

Sanaid SI-60

WZ3146 Size:10mg solid a dramatic increase in caspase-3WZ 3146 is a covalent or irreversible pyrimidine based EGFR inhibitor against EGFR T790M. WZ 3146 was identified by screening an irreversible kinase inhibitor library specifically against EGFR T790M. WZ 3146 potently suppresses the growth of EGFR T790M containing cell lines and inhibits EGFR phosphorylation. WZ 3146 is also effective in murine models of lung cancer driven by EGFR T790M. WZ 3146 may be clinically more effective and better tolerated