LDC1267 ole Formula: C21H19N3O4S
USD90.00
USD112.00
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LDC1267 ole Formula: C21H19N3O4SLDC1267 is a potent and selective TAM kinase inhibitor. LDC1267 displays lower activity against Met, Aurora B, Lck, Src, and CDK8. LDC1267 markedly reduced murine mammary cancer and melanoma metastases dependent on NK cells. The TAM tyrosine kinase receptors Tyro3, Axl and Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl b. Treatment of wild type NK cells with a newly developed small molecule TAM kinase inhibitor
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