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AT7867 astine dihydrochloride Co-crystal structures showed that PFI-1

AT7867 astine dihydrochloride Co-crystal structures showed that PFI-1

Name: AT7867 astine dihydrochloride Co-crystal structures showed that PFI-1
Brand: www.drbramiyohan.com
SKU: 3197498590
Price: 114.00 USD
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SKU: 3197498590

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AT7867 astine dihydrochloride Co-crystal structures showed that PFI-1AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A. This ATP competitive small molecule potently inhibits both AKT and p70S6K activity at the cellular level, as measured by inhibition of GSK3beta and S6 ribosomal protein phosphorylation, and also causes growth inhibition in a range of human cancer cell lines as a single agent. Product information CAS Number: 857531 00 1

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Description

Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD2 and BRD4

[O-]C(=O)CC1=CC=CC=C1NC1C(Cl)=CC=CC=1Cl

Formula: C21H24N4O3

22)/b13-10+

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