Acalabrutinib - CAS# 1420477-60-6 size:10mg solid PAI-039 exerts antithrombotic efficacy in

PAI-039 exerts antithrombotic efficacy in rat models of arterial and venous vascular injury without effecting platelet aggregation

Chemical Name: 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid

in the in vitro signaling assay on primary human CLL cells

2016 May 12

Acalabrutinib - CAS# 1420477-60-6 size:10mg solid PAI-039 exerts antithrombotic efficacy inAcalabrutinib, also known as ACP 196, CAS No. 1420477 60 6, is an orally available inhibitor of Brutons tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP 196 inhibits the activity of BTK and prevents the activation of the B cell antigen receptor (BCR) signaling pathway. This prevents both B cell activation and BTK mediated activation of downstream survival pathways. This leads to an inhibition of the growth of