Lonafarnib - CAS# 193275-84-2 702 Treatment with OTS514 suppressed forkhead
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Lonafarnib - CAS# 193275-84-2 702 Treatment with OTS514 suppressed forkheadLonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras
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