KY02111 - Wnt Inhibitor. CAS# 1118807-13-8 306 It has >700-fold selectivity over

It has >700-fold selectivity over the BET family and 200-fold over the highly homologous bromodomain-containing protein 7 (BRD7)

3 nM in a radioactive enzyme assay and is over 100-fold selective for other histone methyltransferases/HMTs

3 μM for KDM4B

3-(2-carboxyethyl)-4

KY02111 - Wnt Inhibitor. CAS# 1118807-13-8 306 It has >700-fold selectivity overKY02111, CAS No. 1118807 13 8, is a potent and selective Wnt signaling pathway inhibitor discovered by a cell based screening, which promotes differentiation of hESCs iPSCs to cardiomyocytes when used at the second stage of differenitation. Sequential use of CHIR99021 (in the first stage to trigger mesoderm induction of hESCs iPSCs) followed by KY02111 (or XAV939, another Wnt signaling inhibitor) produced robust cardiac differentiation of hESCs iPSCs