AZD-5438 Size:Solid 2 mg ZINC4758640

ZINC4758640

FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) extracted from patent WO 2012064642 A1

Losartan D4 Carboxylic Acid (E-3174 D4) is the deuterium labeled Losartan(EXP-3174)

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

AZD-5438 Size:Solid 2 mg ZINC4758640AZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.