ALS2 Polyclonal Antibody, 50ul Variant Libraries DNA damage response

DNA damage response

it plays an important role in transcriptional regulation

A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls| and repeat numbers in excess of 40 have been described as pathological

Several pseudogenes of this gene have been identified

ALS2 Polyclonal Antibody, 50ul Variant Libraries DNA damage responseThe protein encoded by this gene contains an ATS1 RCC1 like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics.