CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer An isoform lacking exon 6

An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714)

a helical hinge region involved in oligomerization

This gene may play a role in development of the liver

Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription factor activity

CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer An isoform lacking exon 6Cortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F actin and Arp2 3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin