REPS2 Polyclonal Antibody, 50ul Vacuum Filter Studies suggest two alternately used

Studies suggest two alternately used promoters drive tissue-specific expression

It is enriched in the basement membrane of muscles at the neuromuscular junctions

Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia

The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone

REPS2 Polyclonal Antibody, 50ul Vacuum Filter Studies suggest two alternately usedThe product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.