MARCKS Polyclonal Antibody, 50ul[BT-AP05218] Syringe Filter is activated by ATP and

is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types

subcellular location:Shuttles between nucleus and cytoplasm

A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17

Most isoforms share a common C-terminal domain

MARCKS Polyclonal Antibody, 50ul[BT-AP05218] Syringe Filter is activated by ATP andThe protein encoded by MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.