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Rb Polyclonal Antibody, 50ul[BT-AP07693] Cell Transfection The GRLF1 enhances the homologous

SKU: 87921069117

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Rb Polyclonal Antibody, 50ul[BT-AP07693] Cell Transfection The GRLF1 enhances the homologousThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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Description

The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression

which are auxiliary proteins associating with functional Kv-alpha subunits

Functional studies in mice determined that this protein plays a role in vestibular morphogenesis

Five alternatively spliced transcript variants encoding distinct isoforms have been reported

Rb Polyclonal Antibody, 50ul[BT-AP07693] Cell Transfection The GRLF1 enhances the homologousThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

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