S7A14 Rabbit Polyclonal Antibody, 50ul Cell Function Analysis FOXO3 likely functions as a

FOXO3 likely functions as a trigger for apoptosis through expression of genes necessary for cell death

and it is thought to mediate estrogen actions in breast cancer as a primary response gene

which is proteolytically processed to its active form by caspase 1 (CASP1/ICE)

Mutations in this gene have been associated with ataxia-ocular apraxia

S7A14 Rabbit Polyclonal Antibody, 50ul Cell Function Analysis FOXO3 likely functions as aThis gene is predicted to encode a glycosylated cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts neural tissue and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice this gene is expressed in the photoreceptor layer of the retina