PEA-15 Polyclonal Antibody, 100ul[BT-AP07045] Cell fragmentation and collection Alternative splicing results in multiple

Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity

Mapped to a previously identified cluster of cadherin genes on chromosome 16q22

Overexpression of PMEPA1 may play a role in multiple types of cancer

The type II keratins are clustered in a region of chromosome 12q13

PEA-15 Polyclonal Antibody, 100ul[BT-AP07045] Cell fragmentation and collection Alternative splicing results in multiplePEA15 (phosphoprotein enriched in astrocytes 15) encodes a death effector domain containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants.