SETBP Rabbit Polyclonal Antibody, 20ul Immunology Different members of the subfamily

Different members of the subfamily can readily form heterodimers

Pseudogenes are present on chromosomes 5 and 22

The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding

alternative products:At least 4 isoforms| Alpha (shown here)| Alpha-B| Beta and Beta-B| are produced by alternative initiation at Met-1 and Met-27

SETBP Rabbit Polyclonal Antibody, 20ul Immunology Different members of the subfamilyThis gene encodes a protein which contains a several motifs including a ski homology region and a SET binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.