Rb(Phospho Ser780) Polyclonal Antibody, 20ul Dialysis Dynactin binds to both microtubules

Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions

it forms a complex with BRCA1 and BRCA2

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The SH2-binding sites putatively bind CRK| NCK and ABL SH2 domains

Rb(Phospho Ser780) Polyclonal Antibody, 20ul Dialysis Dynactin binds to both microtubulesThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.