TGR5 Polyclonal Antibody, 50ul Rotator Mutations in SGCA result in

Mutations in SGCA result in type 2D autosomal recessive limb-girdle muscular dystrophy

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage

PTM:Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome

The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator

TGR5 Polyclonal Antibody, 50ul Rotator Mutations in SGCA result inGPBAR1 encodes a member of the G protein coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.