Rb(Phospho Thr821) Polyclonal Antibody, 20ul DNA Fragments The encoded protein is expressed

The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains

Reduces all-trans-retinal and 9-cis retinal

subunit:Interacts with MKL1 and SRF

May function in transmigration of leukocytes through epithelial and endothelial tissues

Rb(Phospho Thr821) Polyclonal Antibody, 20ul DNA Fragments The encoded protein is expressedThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.