Rb(Phospho Thr821) Polyclonal Antibody, 50ul Bottles a variant H2A histone that

a variant H2A histone that is enriched on inactivated X chromosomes

Methylation of the genes promoter has been associated with several cancer types

but the biological validity and the full-length nature of some variants have not been determined

This nuclear enzyme is involved in processes such as chromosome condensation

Rb(Phospho Thr821) Polyclonal Antibody, 50ul Bottles a variant H2A histone thatThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.