GGT6 Rabbit Polyclonal Antibody, 20ul Cell Biology The encoded protein downregulates apoptosis

The encoded protein downregulates apoptosis signal-regulating kinase 1

which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a)

is an important signal inducer in acute leuke-mias

Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking| intracellular motility| organelle biogenesis| protein folding| and proteolysis

GGT6 Rabbit Polyclonal Antibody, 20ul Cell Biology The encoded protein downregulates apoptosisGGT6 belongs to the gamma glutamyltransferase (GGT; EC 2. 3. 2. 2) gene family. GGT is a membrane bound extracellular enzyme that cleaves gamma glutamyl peptide bonds in glutathione and other peptides and transfers the gamma glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al. 2008