Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter This component is a heteromeric

This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes

The protein localizes to cell membranes

CHRNA1 encodes an alpha subunit that plays a role in acetlycholine binding/channel gating

COP9 signalosome complex subunit 5 encoded by COPS5 is one of the eight subunits of COP9 signalosome

Nibrin Polyclonal Antibody, 20ul[BT-AP06022] Centrifugal Filter This component is a heteromericMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.