Involucrin Polyclonal Antibody, 50ul Mammalian Expression Mutations in CHEK2 have been

Mutations in CHEK2 have been linked with Li-Fraumeni syndrome

This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function

It also contains a destruction box (D box) that is required for its degradation by the APC

The encoded protein may be involved in cancer and human immunodeficiency virus progression

Involucrin Polyclonal Antibody, 50ul Mammalian Expression Mutations in CHEK2 have beenInvolucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. IVL is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.