Angiomotin-L1 Polyclonal Antibody, 100ul Shaker&Mixing The gamma subunits contain the

The gamma subunits contain the active site of the enzyme| whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family

Mutations in this gene cause nephronophthisis (NPHP)| an autosomal recessive kidney disease characterized by tubular basement membrane disruption| interstitial lymphohistiocytic cell infiltration| and development of cysts at the corticomedullary border of the kidneys

Mutations in this gene have been linked to severe spermatogenic failure and infertility in males

Angiomotin-L1 Polyclonal Antibody, 100ul Shaker&Mixing The gamma subunits contain theAngiomotin like protein 1 encoded by AMOTL1 is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene.