PGE synthase Polyclonal Antibody, 50ul Human Genome Knockout Libraries This enzyme is thought to

This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense

The protein may function in the developing nervous system and play a role in tumorigenesis

The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide

In other organisms

PGE synthase Polyclonal Antibody, 50ul Human Genome Knockout Libraries This enzyme is thought toProstaglandin E synthase encoded by PTGES is a glutathione dependent prostaglandin E synthase. The expression of PTGES has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that PTGES may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain