Human Serine/Arginine-rich Splicing Factor 1, SFRS1 ELISA Kit , 96T In vitro Transcription The activity of this ubiquitin

The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease| the regulation of the cellular response to hypoxia and induction of apoptosis

The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4

A related protein interacts with calcium/calmodulin-dependent serine protein kinase (CASK)

CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D

Human Serine/Arginine-rich Splicing Factor 1, SFRS1 ELISA Kit , 96T In vitro Transcription The activity of this ubiquitinPlays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5' splice site containing pre mRNA. Binds to purine rich RNA sequences, either the octamer, 5' RGAAGAAC 3' (r=A or G) or the decamers, AGGACAGAGC