ARHGEF9 Polyclonal Antibody, 100ul Funnels This gene encodes a nuclear

This gene encodes a nuclear matrix protein

The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system

The protein localizes to the nucleoli and interacts with the U3 snoRNP complex

Found in the granular layer of the cerebellum

ARHGEF9 Polyclonal Antibody, 100ul Funnels This gene encodes a nuclearThe Cdc42 guanine nucleotide exchange factor 9 encoded by ARHGEF9 is a Rho like GTPase that switches between the active (GTP bound) state and inactive (GDP bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.