ZPI Polyclonal Antibody, 20ul Cell Senescence Severe mutations that cause LPL

Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia

moderately in brain and pituitary gland

Sequence analysis identified three transcript variants

targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression

ZPI Polyclonal Antibody, 20ul Cell Senescence Severe mutations that cause LPLThe protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.