Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 20ul Deep Well Plates CEP290 encodes a protein (centrosomal

CEP290 encodes a protein (centrosomal protein 290) with 13 putative coiled-coil domains

Alternative splicing results in multiple transcript variants encoding distinct isoform

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors

and regulation of cell proliferation

Collagen IV alpha2 (Cleaved-Ser1485) Rabbit Polyclonal Antibody, 20ul Deep Well Plates CEP290 encodes a protein (centrosomalAlpha chains of type IV collagen have a non collagenous domain (NC1) at their C terminus frequent interruptions of the G X Y repeats in the long central triple helical domain (which may cause flexibility in the triple helix) and a short N terminal triple helical 7S domain. Type IV collagen is the major structural component of glomerular basement membranes (GBM) forming a 'chicken wire' meshwork together with laminins proteoglycans and entactin