Rb (Acetyl-K873/K874) Polyclonal Antibody, 100ul Deep Well Plates tissue specificity:Highly expressed in testis
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Rb (Acetyl-K873/K874) Polyclonal Antibody, 100ul Deep Well Plates tissue specificity:Highly expressed in testisThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
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