CHIP Polyclonal Antibody, 100ul Gene Synthesis Co-transcription of this gene and

Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2)

The protein encoded by this gene is a plasma membrane anion exchange protein

Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency

Its expression is upregulated during dendritic cells maturation

CHIP Polyclonal Antibody, 100ul Gene Synthesis Co-transcription of this gene andThis gene encodes a protein containing tetratricopeptide repeat and a U box that functions as a ubiquitin ligase cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2.