Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody, 50ul Lysosome catering to diverse testing requirements

catering to diverse testing requirements of our customers

These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II

The upstream stimulatory factor 2 can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes

thus blocking the translation of corresponding proteins

Karyopherin alpha2 (Acetyl Lys22) Rabbit Polyclonal Antibody, 50ul Lysosome catering to diverse testing requirementsThe import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy independent docking of the protein to the nuclear envelope and the second is an energy dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in